As a new kind of anthracene nucleus broad-spectrum antitumor antibiotic, pirarubicin hydrochloride for injection (THP), is developed and explored by H. Umezawa of Micro-biochemistry Research Center of Japan in 1979. It was applied for compounds patent of Japan and was formally initiated from Mercian Business Corp. , producing and marketing by Shenzhen Main Luck Pharmaceuticals Inc. With the approval of Ministry of Public Health of China since 1993, it is proved that comparing with other congener marcellomycin, such as Doxorubicin (ADM) or Epirubicin(EPI), THP has the same effect to major of the cancers(solid tumor or neoplastic hematologic disorder). However, under the same conditions, THP has fewer side effects such as cardiac toxicity, calvities or digestive canal reaction, and sublimates the safety of clinical medication markedly.
Chief feature: 1. It has wide anticancer spectra and high anticancer activity; 2.It is also effective to some tumor cells growing fast to ADM; 3. It can enter tumor cells quickly but has low density in normal tissue; 4. The most outstanding feature of THP is that it has very low side effect, especially the cardiac toxicity, calvities or digestive canal reactions.
Pirarubicin is a breed of “Catalogue of National Essential Drugs” and “Catalogue of National Essential Medical Insurance Drugs”. It becomes the lot basic medication of tumor therapy and has been also generally accredited by National Medical Administrative Command and clinical specialists of tumors.
